Keynote Presentation: Live Single Cell Biology at Ultra-high Throughput for Applications in...

Presented By: Benjamin Yellen, PhD

Speaker Biography: Benjamin has devoted his career in academia and industry to the development of platforms for studying soft condensed matter and living systems. With a background spanning the fields of chemistry, materials science, engineering and computation, Ben has made significant contributions in advancing the understanding of colloidal physics, which led to the development of multiple single cell analysis platform technologies. Ben has co-authored 80+ publications, many of which appear in top journals, such as Nature, Science Advances, PNAS, and he has received numerous teaching and research awards. Ben co-founded Celldom while serving as a tenured professor in the Department of Mechanical Engineering and Materials Science at Duke University, and then moved to a full-time role at Celldom in 2020, where he brings his expertise in computer vision, microscopy, and microfabrication to tackle big problems in rare cell biology.

Webinar: Keynote Presentation: Live Single Cell Biology at Ultra-high Throughput for Applications in T Cell Potency and Small Molecule Drug Testing with Live Q&A

Webinar Abstract: Cell and gene therapies, such as chimeric antigen receptor T cell therapies (CAR-T), have led to some miraculous cures that are transforming the clinical landscape for treating certain types of tumors, such as B cell lymphomas and various blood cancers. Despite its great promise, many barriers continue to limit the effectiveness of CAR-T therapies. One of the largest barriers is developing reliable potency assays for these cell-based medicines, which by nature are highly heterogeneous. An engineered lot will inevitably have a distribution of growth properties, cytolytic activity, gene expression patterns, and secretion profiles, and it is not clear which cell subpopulations are most correlated with positive clinical outcomes. Since each lot of drug uses a patient’s own cells, drug testing must be performed on every patient, which magnifies the need for reliable potency assays.

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