LSD Synthesis in 7 Steps (Educational) | Lysergic acid, organic chemistry, reaction mechanisms

This video does not explain or suggest how to make drugs, and is purely educational and theoretical. A team of chemists recently reported a synthesis of lysergic acid, the precursor of the psychoactive drug LSD, in only 6 laboratory steps. In this video, we will learn why LSD-like scaffolds are of interest to modern drug discovery and look into the chemistry of this short but sweet synthesis.

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Reference:
- Six-Step Synthesis of (±)-Lysergic Acid; https://doi.org/10.1021/acs.joc.2c02564
- Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure–Activity Relationship Studies; https://doi.org/10.1021/acs.jmedchem....

00:00 Why science cares about LSD (lysergic acid diethylamide)
02:11 High-level retrosynthesis of lysergic acid
03:13 Forward synthesis of lysergic acid
06:14 Broader application to pharmaceutically relevant structures

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Some recommended books on organic synthesis:
- Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
- Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
- Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
- Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy)
- Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
- Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)